Scientist (Mouse Genetics and Outsourced Breeding Management)

Start: ASAP (latest 01.04.2026)

Duration: 12 months, potential extension

Workload: 100%

Location: Basel

Team Size: 10

• Provide scientific and operational oversight of external CROs and internal breeding facilities to ensure high-quality delivery and compliance.
• Develop and implement optimized breeding strategies focusing on genetic stability, cost efficiency and timelines while aligning with 3R principles (Replacement, Reduction, Refinement).
• Act as primary contact for external vivarium partners and manage vendor relationships.
• Troubleshoot phenotype drift, health status deviations and breeding challenges.
• Serve as internal subject matter expert for the generation of new transgenic mouse lines using advanced genetic technologies.
• Define and standardize official nomenclature for newly generated lines in line with MGI and international guidelines.
• Maintain and review genotype documentation and molecular validation data such as NGS, Southern Blot and qPCR.
• Monitor welfare of experimental cohorts and define humane endpoints.
• Assess unexpected phenotypes in newly generated lines.
• Establish and implement housing and care standards for outsourced breeding partners.
• Collaborate closely with therapeutic area scientists to support early phenotypic characterization and validation of model utility.

• PhD in Genetics, Molecular Biology, Biotechnology or a related discipline.
• Minimum 3 years of hands-on experience in mouse genetics and colony management.
• Proven track record in generating and validating transgenic mouse models.
• Strong knowledge of breeding strategies and colony optimization aligned with 3R principles.
• Familiarity with FELASA guidelines and animal welfare legislation.
• Experience managing external vendors or CRO relationships.
• Solid understanding of molecular validation techniques including NGS, qPCR and Southern Blot.
• Fluent English required. German is a plus.